As we explore the benefits of brain boosting supplements, it’s important we touch on a molecule that’s been gaining popularity in recent years for its potential role in anti-aging and brain health. NMN, or Nicotinamide Mononucleotide, is a naturally occurring molecule found in every cell of your body. NMN is a precursor to NAD+, a critical coenzyme involved in various cellular processes throughout the body, playing a crucial role in DNA repair, metabolism, and gene expression– all anti aging processes. NAD+ boasts antioxidative properties that reduce accumulating oxidative damage in the brain. There have also been studies showing NAD+ helps improve glucose tolerance and blood sugar, potentially mitigating physical stress on the body.
As we age, NAD+ levels decline, leaving us susceptible to age-related cognitive impairments. In fact, NAD+ levels in the skin decline by 50% by the ages of 40-60. This can lead to mitochondrial dysfunction and oxidative stress – hallmarks of aging/ clear indicators of aging. Studies prove that supplementing with NMN significantly boosts NAD+ levels in humans, leading to better cellular function and providing a safeguard for age-related impairments.
Clinical trials have since shown the benefits of NAD+ on both physical and mental fatigue. Not only does increased NAD+ provide support to healthy cellular function, it can also provide immediate benefits to cognition.
Research has revealed NMN supplementation leading to significant improvements in participant’s fatigue-related symptoms during the day, including drowsiness, dullness, and instability.
A particular study in adults 65 and older showed significantly decreased daytime dysfunction and overall fatigue, as well as improved sleep quality and sleep duration through the night.
There was more evidence toward the benefits of taking NMN in the afternoon in particular. Participants reported better sleep quality and less brain fog the next day compared to the placebo group.
This further leads to the importance of prioritizing rest in order to maintain longevity and reduce stress. While this study in particular was conducted on an older population, mental fatigue has a serious impact on physical fatigue throughout our life regardless of age.
It’s important to note human trials showing the benefit of NAD+ levels on physical performance as well. A 2021 study provided evidence that NAD+ levels lead to better aerobic capacity during exercise, along with the proven benefit of improved insulin sensitivity.
Based on the research above, it appears NAD+ supplementation can be especially beneficial to older populations whose levels are at risk of decline. However, it's possible to say we will only continue to reveal just how beneficial NMN supplementation is for longevity and brain health.
Supplementing with Titan Nutrition’s NMN can help increase energy levels and give your body the best support it needs to reduce the effects of aging.
Stack up your brain power by adding Micronized Creatine to your daily routine. Loss of creatine in the brain as we age plays a large role in age-related neurological diseases and impairs cognitive processing. By supplementing 5g of creatine monohydrate daily, you are not only preventing muscle breakdown and reducing soreness, but also strengthening memory performance and cognition.
Full discussion continued in Part 1 of “Maximizing Brain Power.”
Don’t forget to add Omega-3 fatty acids to your diet. These heart healthy, anti-inflammatory fatty acids are great for the skin and joints but also boost cognition. Omega-3 fatty acids provide the brain with the vital nourishment it needs. These fatty acids are essential components of cell membranes in the brain, particularly the DHA variety, which accounts for a significant portion of our brain's fatty acids. This structural support not only boosts memory but also enhances cognitive abilities. Omega-3s even play a role in reducing inflammation, which has been linked to cognitive decline.
Full discussion continued in Part 2 of “Maximizing Brain Power.”
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Shade, Christopher. “The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule.” Integrative medicine (Encinitas, Calif.) vol. 19,1 (2020): 12-14.
Kim, Mijin et al. “Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study.” Nutrients vol. 14,4 755. 11 Feb. 2022, doi:10.3390/nu14040755
Liao, Bagen et al. “Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study.” Journal of the International Society of Sports Nutrition vol. 18,1 54. 8 Jul. 2021, doi:10.1186/s12970-021-00442-4